ineffective hematopoiesis

Background and objective : Myelodysplastic syndromes ( MDS ) is a heterogeneous group of hematopoietic stem cell disorders characterized by marrow cell dysplasia and ineffective hematopoiesis , with a high risk of transformation into acute myeloid leukemia ( AML ) .

背景和目的：骨髓增生异常综合征（MDS）包括一组以血细胞发育异常和无效造血为特征的造血干细胞疾病，有很高的发生急性髓系白血病（AML）转化的危险性。

Conclusions : apoptosis of bone marrow cells was affected by a lot of factors in MDS , the apoptosis induced by TNF - α and Fas / FasL system can involve in the ineffective hematopoiesis in MDS .

结论：MDS患者骨髓细胞的凋亡受多因素的调节，TNF-α与Fas／FasL系统介导的凋亡以及机体对其调控的失常参与了MDS骨髓无效造血的病理生理过程。